Add the bacon to a large pan and cook over medium heat until crisp.
Spoon the bacon out onto a separate plate but leave the bacon grease in the pan and add the ground beef, salt, pepper, garlic powder, onion powder and chili powder.
Stir and cook until the beef turns a dark brown color then strain out the excess grease from the pan and discard.
Layer the lettuce in the bowl, then add some of the ground beef, bacon, tomatoes, onions, pickles, and cheese if using.
In a small bowl, mix the mayonnaise, ketchup, pickle relish, and mustard together until smooth. Taste and add more relish, ketchup, or mustard as desired.
Drizzle the sauce over the burger bowls and serve.