Preheat oven to 375°F and grease a 9x13 pan, set aside.
Cook the pasta to al dente according to package directions. Place cooked pasta back in the pot when done.
While pasta is cooking, melt 3 tablespoons of butter in a medium saucepan over medium heat. Once butter is melted, whisk in the flour until fully combined. Allow the mixture to lightly bubble for 30 seconds.
Slowly pour the milk into the butter and flour mixture while constantly whisking. Whisk until the mixture has turned light yellow and has slightly thickened into a roux, about 5 minutes.
Stir in cheeses until fully melted. Whisk the spices, buffalo sauce, and ranch to the cheese mixture until combined.
Add the cheese mixture and shredded chicken to the pasta, and mix until evenly coated.
Pour the coated pasta into the prepared baking sheet and spread evenly.
In a separate small bowl, melt the remaining 2 tablespoons of butter. Mix together the melted butter and panko breadcrumbs. Sprinkle panko over top of the pasta.
Bake for 25 to 30 minutes, or until the top is golden brown.