Preheat the oven to 400°F and place a wire rack on top of a rimmed baking sheet and spray with nonstick spray and set aside.
Slice the top off of the jalapeños and carefully remove the seeds inside. Be sure to use gloves when working with jalapeños.
12 large jalapeños
Combine the softened cream cheese with shredded cheddar cheese, brisket, and chili powder. Mix thoroughly.
8 ounces cream cheese, 4 ounces cheddar cheese block, 2 cups finely chopped leftover beef brisket, ½ tablespoon chili powder
Add to a gallon-sized ziplock bag and cut off the corner to make a piping bag. Fill each jalapeño with the mixture.
Wrap each jalapeno with a strip of bacon.
12 slices bacon
Place onto the prepared wire rack-lined baking sheet and bake for 10 minutes on the center rack.
Turn over and bake for another 10 minutes.
Remove jalapenos from the oven and brush with bbq sauce. Turn the broiler on low.
¼ cup bbq sauce
Place the jalapenos 6” under the broiler for 2 minutes, keeping a close eye on them to make sure they don't burn.
Remove from the oven and let cool before serving.